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Procontractile G-protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. A G13-Mediated Signaling Pathway Is Required for Pressure Overload–Induced Cardiac Remodeling and Heart Failure. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Sustained enhancement of residual platelet reactivity after coronary stenting in patients with myocardial infarction compared to elective patients. 2010 May;125(5):e190-6 Althoff TF, Knebel F, Panda A, Mc Ardle J, Gliech V, Franke I, Witt C, Baumann G, Borges AC. Special techniques: live cell microscopy, high resolution voltage and calcium imaging Translational Perspective: Zebrafish vertebrate model is very suitable for the analysis of human genetic disorders. My specific interest is a more detailed understanding of the mechanisms of endothelial damage, endothelial regeneration, neovascularization as well as the interaction between endothelial cells and immune cells.
Long-term follow-up of fenestrated Amplatzer atrial septal occluder in pulmonary arterial hypertension. 2008 Jan;133(1):283-5 • Clinical trails in hematological malignancies • Molecular characterization and subgroup identification in large cohorts of acute leukemia • Analyses of bone marrow stroma compartment • Genome wide expression • Methylation and mutational studies • Implementation of molecular findings in clinical trails with novel targeted therapies Neumann M, Heesch S, Schlee C, Schwartz S, Gökbuget N, Hoelzer D, Konstandin NP, Ksienzyk B, Vosberg S, Graf A, Krebs S, Blum H, Raff T, Brüggemann M, Hofmann WK, Hecht J, Bohlander SK, Greif PA, Baldus CD. Bock J, Mochmann LH, Schlee C, Farhadi-Sartangi N, Göllner S, Müller-Tidow C, Baldus CD. Mochmann LH, Bock J, Ortiz-Tánchez J, Schlee C, Bohne A, Neumann K, Hofmann WK, Thiel E, Baldus CD. Baldus CD, Liyanarachchi S, Mrózek K, Auer H, Tanner SM, Guimond M, Ruppert AS, Mohamed N, Davuluri RV, Caligiuri MA, Bloomfield CD, de la Chapelle A. Scope: RNA-protein interactions in in host and pathogen during infection Techniques: m RNA interactome capture, UV crosslinking of (m)RNPs Translational Perspective: Understanding novel aspects of bacterial infection Beckmann BM, Hoch PG, Marz M, Willkomm DK, Salas M and Hartmann RK. We are primarily interested in cardiovascular diseases, but we can also provide resources for studies of pancreatic beta cells and kidney. My research could contribute to the development of anti-inlammatory and anti-tumor therapies aiming at the endothelium.
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Initiated by entry-level scientists from MDC and Charité, BIH Young Science had its founding event in January 2014. These receptors include the Toll-like receptors (TLRs), the NOD-like receptors (NLRs), RIG-I-like receptors (RLRs) and cytosolic DNA sensors.
The initiative's goal is to intensify regular scientific exchange and discussion, especially on the level of early-career group leaders in interdisciplinary translational research. In addition, recognition of endogenous „damage-associated molecular patterns“ by those or other receptors might be involved in deleterious overinflammation but also in resolution and repair mechanisms in the lung.
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